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We therefore first partitioned our sample into normal A

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cheap oakleys Data from the ADNI Cores were recently integrated to generate a model for the temporal ordering of AD biomarkers38,46, which indicates that A1 42 is the first biomarker to become abnormal, followed by changes in other AD biomarkers (CSF tau, F 18 fluorodeoxyglucose positron emission tomography) and, lastly, the onset of clinical symptoms. Crucially, receiver operating curve analysis of autopsy confirmed AD cases versus normal controls has provided a cutpoint for CSF A1 42 concentration at which diagnostic sensitivity and specificity to AD is maximal (192pgml1) fake oakley sunglasses, yielding correct detection of 96.4% (concentrations below 192pgml1) and correct rejection of 95.2% (concentrations above 192pgml1)37. We therefore first partitioned our sample into normal A (individuals who fell above the 192pgml1 A1 42 cutpoint) and all individuals below this cutpoint expressing AD neuropathology (A+). cheap oakleys

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